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Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract:

Obesity prevalence has increased in recent years.Lifestyle change fuels obesity, but genetic factors cause more than 50% of average variations in obesitystudies on fat mass- and obesity-associated gene (FTO), but the role of these polygenic effectsin the mechanism of obesity remains unclear.on obesity are needed.

Keywords： obesity     genetics     genome-wide association studies     body mass index     fat mass- and obesity-associated gene    

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Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 162-172 doi: 10.1007/s11684-015-0382-2

Abstract: The inverse correlation between the brown adipose tissue activity and body mass suggests its protectiverole against body fat accumulation.

Keywords： brown adipocyte     beige adipocyte     metabolism     obesity    

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Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: anovel model of obesity and puberty

Rahim Ullah, Yan Su, Yi Shen, Chunlu Li, Xiaoqin Xu, Jianwei Zhang, Ke Huang, Naveed Rauf, Yang He, Jingjing Cheng, Huaping Qin, Yu-Dong Zhou, Junfen Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 266-276 doi: 10.1007/s11684-017-0530-y

Abstract:

Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatalIn the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaningWe also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity.Results showed that feeding with HFD induces fat deposition and obesity in pups.Our model suggests good construction validity of obesity and precocious puberty.

Keywords： postnatal HFD feeding     obesity     kisspeptin     HPG axis     precocious puberty    

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Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscularfat in Duroc pigs

Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 335-341 doi: 10.15302/J-FASE-2017152

Abstract: Intramuscular fat (IMF) is a major meat-quality trait in pigs.The content of IMF is directly associated with the taste and flavor of pork.Genome-wide association study is a powerful tool to detect genomic regions associated with phenotypicIn this region, eight SNPs were significantly associated with IMF content.

Keywords： Duroc pigs     genome-wide association analysis     intramuscular fat    

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Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 459-466 doi: 10.1007/s11684-021-0841-x

Abstract: FANCA was the most frequently mutated gene (n = 29), followed by BRCA2 (nburden, higher rate of cytogenetic abnormalities, less epigenetic regulation, and fewer spliceosome gene

Keywords： Fanconi anemia     aplastic anemia     hematologic malignancy     germline predisposition    

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Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture

Frontiers of Medicine doi: 10.1007/s11684-023-1023-9

Abstract: the risk of osteoporosis, but the association of early-life undernutrition combined with adulthood obesityGeneral obesity was assessed using the body mass index (BMI), and abdominal obesity was evaluated withCompared to the nonexposed group, the group with fetal, childhood, and adolescence famine exposure was associatedSignificant interactions were observed between fetal famine exposure and general obesity with fractureand WHR, the group of women who underwent fetal famine exposure and had both general and abdominal obesity

Keywords： famine     obesity     body mass index     waist-to-hip ratio     low-energy fracture    

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Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 158-163 doi: 10.1007/s11684-009-0042-5

Abstract: The regulatory effect of basic fibroblast growth factor (bFGF) mediated by recombinant adeno-associated

Keywords： tetracycline regulatory system     adeno-associated virus     basic fibroblast growth factor     gene regulation    

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Analyzing the distinguishing factors that affect childhood obesity in South Korea

So Jung Yang, Hun-Sung Kim, Kun-Ho Yoon

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 707-716 doi: 10.1007/s11684-018-0660-x

Abstract:

Understanding obesity in children is crucial because it can lead to adulthood obesity and result inDistinctive factors associated with obesity in adults have been described, but distinctive factors relatedWe analyzed the correlation between the percentage of body mass index and lifestyle habits by conductingOur study revealed that the computing hours in elementary school students with overweight and obesitywere significantly correlated with the percentage of body mass index (r = 0.29 on school days

Keywords： screen time     quality of life     eating habits     childhood obesity     percentage of body mass index    

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Multiple effects of grape seed polyphenolics to prevent metabolic diseases

Torey ARVIK, Hyunsook KIM, James SEIBER, Wallace YOKOYAMA

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 351-361 doi: 10.15302/J-FASE-2018235

Abstract:

Obesity is increasing in developing countries.Population studies show a relationship between affluence and obesity.Animal models of obesity consistently show that grape seed procyanidins prevent increases in body andminal adipose weight gain, plasma cholesterol, liver weight gain and inflammation in animals on high fatGut bacteria are recognized as significant contributors to obesity and obesity related metabolic diseases

Keywords： grape seed     obesity     procyanidins     high fat     microbiota     animal models    

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Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 178-182 doi: 10.1007/s11684-016-0442-2

Abstract:

Metastasis-associated gene 1 (MTA1) controls a series of biological processes in tumor progressionTumor progression is a complex process regulated by a gene network.The global cancer gene regulatory network must be analyzed to determine the position of MTA1 in the molecularnetwork and its cooperative genes by further exploring the biological functions of this gene.GO and KEGG pathway analyses were conducted with DAVID and gene network analysis via STRING and Cytoscape

Keywords： metastasis-associated gene 1     colon cancer     bioinformatics    

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Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 93-98 doi: 10.1007/s11684-007-0018-2

Abstract: lymphomas and reactive lymph node hyperplasia, and to perform an initial bioinformatic analysis on a novel genelymphomas and reactive lymph node hyperplasia were respectively marked with biotin and hybridized with GeneInitial bioinformatic analysis was then performed on a novel gene named KIAA0372, whose function hasUsing Gene Expression Chips, many differentially expressed genes were uncovered.

Keywords： bioinformatic analysis     functional     KIAA0372     detection     Microarray    

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Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 438-447 doi: 10.1007/s11684-020-0826-1

Abstract: Thoracic aortic dissection (TAD) without familial clustering or syndromic features is known as sporadic TAD (STAD). So far, the genetic basis of STAD remains unknown. Whole exome sequencing was performed in 223 STAD patients and 414 healthy controls from the Chinese Han population (N = 637). After population structure and genetic relationship and ancestry analyses, we used the optimal sequence kernel association test to identify the candidate genes or variants of STAD. We found that COL3A1 was significantly relevant to STAD (P = 7.35 × 10−6) after 10 000 times permutation test (P = 2.49 × 10−3). Moreover, another independent cohort, including 423 cases and 734 non-STAD subjects (N = 1157), replicated our results (P = 0.021). Further bioinformatics analysis showed that COL3A1 was highly expressed in dissected aortic tissues, and its expression was related to the extracellular matrix (ECM) pathway. Our study identified a profile of known heritable TAD genes in the Chinese STAD population and found that COL3A1 could increase the risk of STAD through the ECM pathway. We wanted to expand the knowledge of the genetic basis and pathology of STAD, which may further help in providing better genetic counseling to the patients.

Keywords： sporadic thoracic aortic dissection     exome sequencing     gene COL3A1     case–control study     extracellular    

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Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated withTNF-alpha-308 gene polymorphisms in rheumatoid arthritis patients

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 220-224 doi: 10.1007/s11684-010-0025-6

Abstract: peripheral blood monocular cells (PBMCs) and the association of the inhibitory effect with TNF-α-308 geneGene polymorphism at A-G site 308 in the promoter region of TNF-α gene was detected in 42 It was concluded that gene polymorphism at TNF-α-308 sites may relate to the secretion of TNF-α

Keywords： arthritis     rheumatoid     molonuclear cells     tumor necrosis factor     gene polymorphisms     triptolid    

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: mutation (NM_001301860: p.1835A>T/p.D612V) of Lipin3 in a large family with hypertriglyceridemia (HTG) and obesityWe found that Lipin3-heKO mice exhibited obvious obesity, HTG, and non-alcoholic fatty liver disorderOur study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 90-95 doi: 10.1007/s11684-010-0021-x

Abstract: This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene

Keywords： cyclooxygenase-2 gene     single nucleotide polymorphisms     susceptibility     primary hepatocellular carcinoma    

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Title Author Date Type Operation

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Journal Article

Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: anovel model of obesity and puberty

Rahim Ullah, Yan Su, Yi Shen, Chunlu Li, Xiaoqin Xu, Jianwei Zhang, Ke Huang, Naveed Rauf, Yang He, Jingjing Cheng, Huaping Qin, Yu-Dong Zhou, Junfen Fu

Journal Article

Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscularfat in Duroc pigs

Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG

Journal Article

Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Journal Article

Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture

Journal Article

Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Journal Article

Analyzing the distinguishing factors that affect childhood obesity in South Korea

So Jung Yang, Hun-Sung Kim, Kun-Ho Yoon

Journal Article

Multiple effects of grape seed polyphenolics to prevent metabolic diseases

Torey ARVIK, Hyunsook KIM, James SEIBER, Wallace YOKOYAMA

Journal Article

Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Journal Article

Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding

Journal Article

Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Journal Article

Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated withTNF-alpha-308 gene polymorphisms in rheumatoid arthritis patients

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Journal Article

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Journal Article